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It is also used nonmedically for physique and performanceenhancing purposes
comprar productos para adelgazar was also prescribed offlabel as a pharmaceutical performance enhancement to weight lifters and other athletes The primary urinary metabolites are detectable for up to 3 days and a recently discovered hydroxymethyl metabolite is found in urine for up to 19 days after a single 5 mg oral dose The elimination halflife of metandienone is about 3 to 6 hours It has very low affinity for human serum sex hormonebinding globulin SHBG about 10 of that of testosterone and 2 of that of DHT As with other 17αalkylated AAS metandienone may be hepatotoxic especially with prolonged use of high doses
Unlike methyltestosterone owing to the presence of its C12 double bond metandienone does not produce 5αreduced metabolites As such 5αreductase inhibitors like finasteride and dutasteride do not reduce the androgenic effects of metandienone oxandrolona em farmácia de manipulação of metandienone include symptoms of masculinization like acne increased hair growth voice changes and increased sexual desire estrogenic effects like fluid retention and breast enlargement and liver damage
While the rate of aromatization is reduced relative to that for testosterone or methyltestosterone the estrogen produced is metabolismresistant and hence metandienone retains moderate estrogenic activity The drug is an agonist of the androgen receptor AR the biological target of androgens like testosterone and dihydrotestosterone DHT and has strong anabolic effects and moderate androgenic effects While metandienone is controlled and no longer medically available in the US it continues to be produced and used medically in some other countries
Metandienone is used for physique and performanceenhancing purposes by competitive athletes bodybuilders and powerlifters Metandienone is readily available without a prescription in certain countries such as Mexico and is also manufactured in some Asian countries Achat complément alimentaire minceur discount is currently a controlled substance in the United States and United Kingdom and remains popular among bodybuilders
There are many known cases of doping in sports with metandienone by professional athletes Metandienone is the generic name of the drug and its INNTooltip International Nonproprietary Name while methandienone is its BANTooltip British Approved Name and métandiénone is its DCFTooltip Dénomination Commune Française After CIBAs patent exclusivity period lapsed other manufacturers began to market generic metandienone in the US In 1965 the FDA pressured CIBA to further document its legitimate medical uses and reapproved the drug for treating postmenopausal osteoporosis and pituitarydeficient dwarfism It is a modification of testosterone with a methyl group at the C17α position and an additional double bond between the C1 and C2 positions
Metandienone also known as 17αmethylδ1testosterone or as 17αmethylandrost14dien17βol3one is a synthetic androstane steroid and a 17αalkylated derivative of testosterone The coadministration of an antiestrogen such as an aromatase inhibitor like anastrozole or a selective estrogen receptor modulator like tamoxifen can reduce or prevent such estrogenic side effects As such it can cause side effects such as gynecomastia and fluid retention Methandienone binds to and activates the androgen receptor AR in order to exert its effects Estrogenic side effects such as gynecomastia and fluid retention can also occur Metandienone along with other AAS is a schedule III controlled substance in the United States under the Controlled Substances Act

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