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CONTRAVE is not recommended for use in patients with severe hepatic impairment see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY verletztenkinderseelenhelfen may be more sensitive to the central nervous system adverse effects of CONTRAVE When given to pregnant rabbits during organogenesis nondoserelated increases in incidence of fetal malformations and skeletal variations were observed at the lowest dose tested 25 mgkgday approximately 2 times the MRHD on a mgm basis and greater The prospectively observed rate of cardiovascular malformations in pregnancies with exposure to bupropion in the first trimester from the international Pregnancy Registry was 13 9 cardiovascular malformations out of 675 firsttrimester maternal bupropion exposures which is similar to the background rate of cardiovascular malformations approximately 1
It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke pereraadio should be used with a reducedcalorie diet and increased physical activity It is uniquely designed to reduce hunger and control cravings so you can lose weight and keep it off The content on this page is for informational and educational purposes only and does not constitute professional medical advice These costeffective alternatives for most patients offer the same benefits as their brandname Consider the clever choice of switching to generic prescriptions
The pooled analyses of placebocontrolled trials in adults with MDD or other psychiatric disorders included a total of 295 shortterm trials median duration of two months of 11 antidepressant drugs in over 77000 patients The pooled analyses of placebocontrolled trials of antidepressant drugs in children and adolescents with MDD obsessive compulsive disorder OCD or other psychiatric disorders included a total of 24 shortterm trials of nine antidepressant drugs in over 4400 patients Shortterm clinical trials did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond age 24 there was a reduction with antidepressants compared with placebo in adults aged 65 and older Pooled analyses of shortterm placebocontrolled trials of antidepressant drugs selective serotonin reuptake inhibitors SSRIs and others show that these drugs increase the risk of suicidal thinking and behavior suicidality in children adolescents and young adults ages 18 to 24 with major depressive disorder MDD and other psychiatric disorders
The relationship of bupropion exposure and these seizures is unclearThe safety and effectiveness of CONTRAVE in pediatric patients below the age of 18 have not been established and the use of CONTRAVE is not recommended in pediatric patientsOf the 3239 subjects who participated in clinical trials with CONTRAVE 62 2 were 65 years and older and none were 75 years and older The average daily infant exposure assuming 150 mLkg daily consumption to bupropion and its active metabolites was 2 of the maternal weightadjusted dose There was no evidence of carcinogenicity in a twoyear dietary study with naltrexone in male and female miceLifetime carcinogenicity studies of bupropion were performed in rats and mice at doses up to 300 and 150 mgkgday respectively
It is not known if CONTRAVE is safe and effective when taken with other prescription overthecounter or herbal weight loss products In a subset of 124 patients 79 CONTRAVE 45 placebo body composition was measured using dual energy Xray absorptiometry DEXA Changes in glycemic control observed from baseline to Week 56 among patients with type 2 diabetes and obesity assigned to either CONTRAVE 32 mg360 mg or placebo are shown in Table 8 The DEXA assessment showed that mean total body fat mass decreased by 47 kg 117 in the CONTRAVE group vs 14 kg 43 in the placebo group at Week 52LOCF treatment difference 33 kg 74 p Approximately 24 of patients treated with CONTRAVE and 12 of patients treated with placebo discontinued treatment because of an adverse reaction see ADVERSE REACTIONS
This medication may be available under multiple brand names andor in several different forms We strive to provide medication across Europe at your doorsteps for overall wellbeing Wegovy Semaglutide mimics the action of GLP1 a natural hormone that helps regulate blood sugar levels reduce appetite and promote a feeling of fullness Contrave contains Bupropion an antidepressant that may help reduce food cravings while naltrexone is used to treat alcohol and opioid dependence and may contribute to reducing food cravings and appetite CONTRAVE is not approved to treat depression or other mental illnesses or to help people quit smoking smoking cessation
Patients with major depressive disorder both adult and pediatric may experience worsening of their depression andor the emergence of suicidal ideation and behavior suicidality or unusual changes in behavior whether or not they are taking antidepressant medications and this risk may persist until significant remission occurs In Hgh Eestis bupropion produced amphetaminelike and cocainelike discriminative stimulus effects in drug discrimination paradigms used to characterize the subjective effects of psychoactive drugs In primate models assessing the positive reinforcing effects of psychoactive drugs bupropion was selfadministered intravenously
Naltrexone administered orally to rats caused a significant increase in pseudopregnancy and a decrease in pregnancy rates in rats at 100 mgkgday approximately 50 times the MRHD of the naltrexone component in CONTRAVE on a mgm basis There was limited evidence of a weak genotoxic effect of naltrexone in one gene mutation assay in a mammalian cell line in the Drosophila recessive lethal assay and in nonspecific DNA repair tests with E There was no evidence of carcinogenicity in a twoyear dietary study with naltrexone in male and female mice