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As of lifesbestmedicine it was thought that uniquely among 17αalkylated AASs oxandrolone showed little to no hepatotoxicity even at high doses Like other AASs oxandrolone may worsen hypercalcemia by increasing osteolytic bone resorption valued oxandrolones supposedclarification needed low hepatotoxicity relative to most other orally active AASs Oxandrolone has been used illicitly by bodybuilders and athletes for its musclebuilding effects as a doping agent in sports Children with idiopathic short stature or Turner syndrome were given doses of oxandrolone far smaller than those given to people with burns to minimize the likelihood of virilization and premature maturationincomprehensible Medical research established the effectiveness of oxandrolone in aiding the development of girls with Turner syndrome
In an attempt to compensate for the exogenous increase in androgens the body may reduce testosterone production via testicular atrophy and inhibition of gonadotropic activity Like other androgens oxandrolone can cause or worsen acne and priapism unwanted or prolonged erections Women who are administered oxandrolone may experience virilization irreversible development of masculine features such as voice deepening hirsutism menstruation abnormalities malepattern hair loss and clitoral enlargement
Oxandrolone is based on the tetracyclic steroid framework which consists of three cyclohexane rings A B and C and one cyclopentane ring D Activation of the androgen receptor stimulates protein synthesis which increases muscle growth lean body mass and bone mineral density where can I buy Clenbuterol of oxandrolone for the androgen receptor is about 03 of that of metribolone It may worsen edema when taken alongside corticosteroids or adrenocorticotropic hormone As of 2004 it was known that oxandrolone greatly increases warfarins bloodthinning effect sometimes dangerously so
Additional brand names existed for products that were manufactured for the steroid black market Oxandrolone has also been sold under the brand names Antitriol Spain Anatrophill France Lipidex Brazil Lonavar Argentina Australia Italy Protivar and Vasorome Japan among othersAs of 2016 among those using oxandrolone for nonmedical purposes it has been referred to colloquially as Var a shortened form of the old brand name Anavar This product was eventually discontinued and replaced in the United States with a new name of Oxandrin which as of 2011 was the sole remaining brand name for oxandrolone in the United States The original brand name of oxandrolone was Anavar which was marketed in the United States and the Netherlands It is also known as 2oxa17αmethyl5αdihydrotestosterone 2oxa17αmethylDHT or as 2oxa17αmethyl5αandrostan17βol3one and is DHT with a methyl group at the C17α position and the C2 carbon replaced with an oxygen atom
In the United States the FDAs Endocrinologic and Metabolic Drugs Advisory Committee unanimously concluded in 1984 that there was no evidence of efficacy for oxandrolone The drug is a controlled substance in many countries so nonmedical use for purposes such as improving physique and performance has been generally illicit
These benefits do not appear to be accompanied by an increased risk of infection hyperglycemia or hepatic dysfunction which underscores the safety profile of oxandrolone in severe burn patient population In Anavar prezzo farmacia of severe burn injuries clinical trials have demonstrated the therapeutic advantages of oxandrolone and it was widely adopted as a standard treatment protocol in burn centers globally Milder side effects in women were increased sexual desire symptoms of hyperandrogenism such as acne and symptoms of masculinization such as increased hair growth and voice changes It has strong anabolic effects and weak androgenic effects which gave it a mild side effect profile in that regard and made it especially suitable for use in women As of August 2023 the AASs that remained available for medical use in the US were testosterone testosterone cypionate testosterone enanthate testosterone undecanoate methyltestosterone fluoxymesterone and oxymetholone
This structural element is what gives oxandrolone its distinctive chemical identity within the class of anabolic steroids The overall structure of oxandrolone is distinguished by these modifications to the standard steroid nucleus which contribute to its unique properties as an anabolic steroid The reduced ratio of anabolic to androgenic activity of oxandrolone motivated its medical use in children and women because less androgenic effect implies less risk of virilization As such the researchers stated although oxandrolone cannot be implicated as stimulatory in gynecomastia a possible relationship should be considered in clinicians using oxandrolone in adolescents for growth stimulation Because it is more anabolic than androgenic women and those seeking less intense steroid regimens used it particularly often