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As of 2019 oxandrolone was prescribed offlabel for the development of girls with Turner syndrome and counteract wasting of diverse origin Oxandrolone was recommended as an adjunctive therapy alongside insulin metformin and closely monitored propranolol in severe burn patients for metabolic and nutritional support Oxandrolone improves weight regain bone mineral density lean body mass and accelerates wound healing for donor graft sites Data analysis confirms oxandrolones advantage in promoting skin healing as an adjunct therapy for adult burn patients Oxandrolone has been researched and prescribed as a treatment for a wide variety of conditions On nhand 2019 Gemini asked FDA to withdraw approval for all doses of the drug stating that they were no longer marketing it
The drug is metabolized primarily by the kidneys and to a lesser extent by the liver acheter gel testostérone in contrast to DHT is believed to underlie oxandrolones preserved anabolic potency Due to its lactone bridge oxandrolone is resistant to inactivation by 3αhydroxysteroid dehydrogenase in skeletal muscle The oxygen atom in the lactone bridge replaces a carbon atom at position 2 of the steroid nucleus classifying oxandrolone as a 2oxasteroid
Oxandrolone was first made by Raphael Pappo and Christopher J brickobotik at Searle Laboratories now part of Pfizer and they first described the drug in 1962 Oxandrolone is a synthetic androstane steroid and a 17αalkylated derivative of DHT About 28 of an oral dose of oxandrolone is eliminated unchanged in the urine and 3 is excreted in the feces Oxandrolone is the only AAS that is not primarily or extensively metabolized by the liver and this is thought to be related to its diminished hepatotoxicity relative to other AASs
In an attempt to compensate for the exogenous increase in androgens the body may reduce testosterone production via testicular atrophy and inhibition of gonadotropic activity Like other androgens oxandrolone can cause or worsen acne and priapism unwanted or prolonged erections Women who are administered oxandrolone may experience virilization irreversible development of masculine features such as voice deepening hirsutism menstruation abnormalities malepattern hair loss and clitoral enlargement
This structural element is what gives oxandrolone its distinctive chemical identity within the class of anabolic steroids The overall structure of oxandrolone is distinguished by these modifications to the standard steroid nucleus which contribute to its unique properties as an anabolic steroid The reduced ratio of anabolic to androgenic activity of oxandrolone motivated its medical use in children and women because less androgenic effect implies less risk of virilization As such the researchers stated although oxandrolone cannot be implicated as stimulatory in gynecomastia a possible relationship should be considered in clinicians using oxandrolone in adolescents for growth stimulation Because it is more anabolic than androgenic women and those seeking less intense steroid regimens used it particularly often
Like other AASs oxandrolone is an agonist of the androgen receptor similar to androgens such as testosterone and DHT The gynecomastia developed during oxandrolone therapy in 19 of the boys and after the therapy was completed in 14 of the boys and 10 of the boys had transient gynecomastia while 23 had persistent gynecomastia that necessitated mastectomy Unlike some AASs oxandrolone does not generally cause gynecomastia because it is not aromatized into estrogenic metabolites Because of these side effects doses given to women and children are minimized and people are usually monitored for virilization and growth abnormalities